1999- 2007: OCD: ADHD: Childhood Bipolar Disorder: The Evolution of a Diagnosis ; part 20

FDA Approves Risperdal: Appears that Biederman, Wozniak,Wilens all had the same thought.

Risperidone Treatment for Juvenile Bipolar Disorder: A Retrospective Chart Review.-1999


Journal of the American Academy of Child & Adolescent Psychiatry. 38(8):960-965, August 1999.

FRAZIER, JEAN A. M.D.; MEYER, MICHELE C. M.D.; BIEDERMAN, JOSEPH M.D.; WOZNIAK, JANET M.D.; WILENS, TIMOTHY E. M.D.; SPENCER, THOMAS J. M.D.; KIM, GRACE S. M.A.R.; SHAPIRO, STEPHANIE B.A. -1999

"Abstract:
Objective

To Investigate the effectiveness and tolerability of the atypical neuroleptic risperidone in the treatment of juvenile mania. Method This is a retrospective chart review of outpatients with the diagnosis of bipolar disorder (DSM-IV) treated with risperidone at a university center. Response to treatment was evaluated using the Clinical Global Impression Scale (CGI) with separate assessments of mania, psychosis, aggression, and attention-deficit/hyperactivity disorder (ADHD). Results Twenty-eight youths (mean SD age, 10.4 3.8 years) with bipolar disorder (25 mixed and 3 hypomanic) who had been treated with risperidone were identified. These children received a mean dose of 1.7 1.3 mg over an average period of 6.1 8.5 months. Using a CGI Improvement score of <=2 (very much/much improved) to define robust improvement, 82% showed improvement in both their manic and aggressive symptoms, 69% in psychotic symptoms, but only 8% in ADHD symptoms.

Conclusions Although limited by its retrospective nature, this study suggests that risperidone may be effective in the treatment of manic young people and indicates the need for controlled clinical trials of risperidone and other atypical neuroleptics in juvenile mania.

J. Am.Acad. Child Adolesc. Psychiatry, 1999, 38(8):960-965. Copyright 1999 (C) American Academy of Child and Adolescent Psychiatry"

FDA Approves Risperdal[antipsychotic]for 10+ year old Bipolar Children